- Recruiting
NCT04171843: Phase 1/2: Allogeneic anti-BCMA CAR T cells PBCAR269A With or Without Nirogacestat RRMM
Updated: May 26, 2022
NCT04171843: Phase 1/2: PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
allogeneic anti-BCMA CAR T cells PBCAR269A

A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
This is a Phase 1/2a, nonrandomized, open-label, parallel assignment, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR269A, with or without nirogacestat, in adults with r/r MM.
Study subjects in Cohort A will receive PBCAR269A and study subjects in Cohort B will receive PBCAR269A and nirogacestat. At each dose level, study subjects in Cohort A and Cohort B will receive the same dose of PBCAR269A. In Cohort B, all study subjects will follow the same dosing regimen of nirogacestat.
Sponsor
Multiple Locations
ClinicalTrials.gov Identifier: NCT04171843
Official Title: A Phase 1/2a, Open-label, Dose-escalation, Dose-expansion Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
First Posted : November 21, 2019
Click here for details on ClinicalTrials.gov
Click here for details on Cancer.gov
allogeneic anti-BCMA-CAR T cells PBCAR269A
Allogeneic Anti-BCMA-CAR T-cells PBCAR269A (Code C171066)
Allogeneic Anti-BCMA-CAR T-cells PBCAR269A
Genetic: PBCAR269A
allogeneic anti-BCMA-CAR T cells PBCAR269A
Drug: Fludarabine
Drug: Cyclophosphamide
Drug: Nirogacestat
Nirogacestat (Code C82383)
Nirogacestat
NIROGACESTAT
PF-03084014
gamma secretase inhibitor PF-03084014
- California: University of California San Francisco
- California: City of Hope Duarte
- Massachusetts: Dana-Farber Cancer Institute/Harvard Cancer Center Boston
- Texas: The University of Texas MD Anderson Cancer Center Houston
- New York: Columbia University Medical Center New York
Locations
United States, California
United States, Massachusetts
United States, New York
United States, Texas