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NCT03582033: Phase 1 - A Safety Study of SEA-BCMA in Patients With Multiple Myeloma

Updated: Jul 15, 2022

NCT03582033: Phaae 1 - A Safety Study of SEA-BCMA in Patients With Multiple Myeloma

sea bcma

This trial will study SEA-BCMA to find out whether it is an effective treatment for multiple myeloma (MM) and what side effects (unwanted effects) may occur.

The study will have several parts. In Parts A and B, participants get SEA-BCMA by itself. This part of the study will find out how much SEA-BCMA should be given for treatment and how often. It will also find out how safe the treatment is and how well it works.

In Part C of the study, participants will get SEA-BCMA and dexamethasone. In Parts D and E, participants will get SEA-BCMA, dexamethasone, and either pomalidomide or nirogacestat. Dexamethasone and pomalidomide are both drugs that can be used to treat multiple myeloma. Nirogacestat is an experimental drug that can be used with SEA-BCMA to treat multiple myeloma. These parts of the study will find out whether these drugs are safe when used together.


Seagen Inc. Identifier: NCT03582033

Official Title: A Phase 1 Study of SEA-BCMA in Patients With Relapsed or Refractory Multiple Myeloma

First Posted : July 10, 2018

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SEA-BCMA is a Novel Empowered Antibody Targeting BCMA for Multiple Myeloma

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Nirogacestat - gamma secretase inhibitor PF-03084014

View this agent in the NCI Thesaurus

View NCI Drug Dictionary info

Lenalidomide: National Cancer Institute

Lenalidomide: MedlinePlus Drug Information

Pomalidomide: National Cancer Institute

Pomalidomide : MedlinePlus Drug Information



Drug: dexamethasone

Drug: pomalidomide

Drug: nirogacestat


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