• Recruiting

NCT03289299 : Phase 2 - Agg. Smoldering Curative Approach Eval. Novel Therapies & Transplant ASCENT

Updated: May 23

ASCENT TRIAL

Dara-KRd

ASCENT trial myeloma

Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant (ASCENT)


This study evaluates the use of carfilzomib, lenalidomide, daratumumab, and dexamethasone in subjects with high-risk smoldering multiple myeloma (SMM). Subjects will receive treatment in 3 phases - induction (6 cycles), consolidation (6 cycles), and maintenance (12 cycles). Each cycle is 28 days.


Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant (ASCENT)


Sponsor

International Myeloma Foundation


Collaborators

Amgen

Janssen Scientific Affairs, LLC

Celgene

Trevie, Inc.

 

ClinicalTrials.gov Identifier: NCT03289299


Official Title: Aggressive Smoldering Curative Approach Evaluating Novel Therapies (ASCENT): A Phase 2 Trial of Induction, Consolidation, and Maintenance in Subjects With High Risk Smoldering Multiple Myeloma (SMM)

First Posted : September 20, 2017


Click here for details on ClinicalTrials.gov

 

Daratumumab : National Cancer Institute

Daratumumab : MedlinePlus Drug Information


Carfilzomib : National Cancer Institute

Carfilzomib : MedlinePlus Drug Information


Lenalidomide: National Cancer Institute

Lenalidomide: MedlinePlus Drug Information


Dexamethasone : National Cancer Institute

Dexamethasone : MedlinePlus Drug Information

 

Aggressive Smoldering Curative Approach Evaluating Novel Therapies (ASCENT): A Phase 2 Trial of Induction, Consolidation and Maintenance in Subjects with High Risk Smoldering Multiple Myeloma (SMM): Initial Analysis of Safety Data

Online Publications; Scientific Abstracts

62nd ASH Annual meeting

653.Myeloma/Amyloidosis: Therapy, excluding Transplantation

November 5, 2020


https://ashpublications.org/blood/article/136/Supplement%201/35/472060/Aggressive-Smoldering-Curative-Approach-Evaluating

 

Drug: Carfilzomib

Drug: Lenalidomide

Drug: Daratumumab

Drug: Dexamethasone

 

-Multiple locations

- Illinois: University of Chicago

- Florida: Moffitt Cancer Center Tampa

- Minnesota: Mayo Clinic Rochester Minnesota

- North Carolina: Levine Cancer Institute Charlotte

- New York: New York Presbyterian / Weill Cornell Medical College New York

- Wisconsin: Medical College Of Wisconsin Milwaukee

 

Locations


United States, Florida

United States, Illinois

United States, Indiana

United States, Kansas

United States, Maryland

United States, Minnesota

United States, New York

United States, North Carolina

United States, Washington

United States, Wisconsin



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