NCT03218683: Phase 1/2: Study of AZD5991 Alone or with Venetoclax in Relapsed Hem Malignancies
Updated: Jun 15, 2022
NCT03218683: Phase 1/2: Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.
Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.
This study is a multicenter, open-label, nonrandomized, sequential group, dose-escalation study to assess safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of ascending doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies Part 1 of the study is monotherapy dose escalation. Closed November 2020 Part 2 of the study is monotherapy expansion groups for relapsed/refractory chronic lymphocytic leukaemia (CLL), AML/ myelodysplastic syndromes (MDS), and multiple myeloma (MM). Closed November 2020 Part 3 is a sequential, dose-escalation study of the combination of AZD5991 and venetoclax in subjects with relapsed/refractory AML
Sponsor
AstraZeneca
Multiple Locations
ClinicalTrials.gov Identifier: NCT03218683
Official Title: A Phase 1/1b/2a, 3-Part, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Ascending Doses of AZD5991 Monotherapy and in Combination With Venetoclax in Subjects With Relapsed or Refractory Haematologic Malignancies
First Posted: July 14, 2017
Click here for details on ClinicalTrials.gov
Drug: AZD5991
Drug: AZD5991 + Venetoclax
Mcl-1 Inhibitor AZD5991
AZD-5991
AZD5991
Mcl-1 Inhibitor AZD5991
MCL1 Inhibitor AZD5991
4-(4-((2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide
ABT-0199
ABT-199
ABT199
GDC-0199
RG7601
Venclexta
Venclyxto
Venetoclax
VENETOCLAX
Nat Commun; 2018 Dec
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Locations
United States, California
United States, Colorado
United States, Georgia
United States, Massachusetts
United States, Missouri
United States, New York
United States, Ohio
United States, Oregon
United States, Tennessee
United States, Texas