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Different stages of Multiple Myeloma - As per originally used Durie-Salmon staging system

Updated: Mar 8


Durie-Salmon staging system


Durie-Salmon staging system for multiple myeloma



Stage 1

Low Myeloma cell mass: <0.6 × 1012 cells/m2 + all of the following criteria present:

  • Hemoglobin above 10 g/dl

  • Serum Immunoglobulins level - IGA less than 3 g/dl and Serum IGG less than 5 g/dl

  • Serum Calcium level within normal limits

  • No generalized lytic bone lesions

  • Urine monoclonal protein excretion less than 4 grams in 24 hour urine collection

 

Stage 3:

  1. Myeloma cell mass: >1.2 × 1012 cells/m2 + one or more of the following criteria present:

  • Hemoglobin less than 8.5 g/dl

  • Immunoglobulins level Serum IGA more than 5 g/dl or Serum IGG more than 7 g/dl

  • Serum Calcium level more than 12 mg/dl

  • Lytic bone lesions

  • Urine monoclonal protein excretion greater than 12 grams in 24 hour urine collection


Stage 3A = Creatinine less than 2 mg/dl

Stage 3B = Creatinine more than 2 mg/dl

 

Stage 2

Intermediate Myeloma cell mass: Neither stage 1 nor stage 3

 

Reference:


A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

B G Durie, S E Salmon

Cancer; 1975 Sep

https://pubmed.ncbi.nlm.nih.gov/1182674/

Click here to see details.

 

Related Multiple Myeloma Clinical Trials Post:


What are the different stages of Multiple Myeloma? REVISED - INTERNATIONAL STAGING SYSTEM (R-ISS)

Click here to see details



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