• Active, not recruiting

NCT03338972: Phase 1 - Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143 in RRMM

Updated: Jun 15


Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

FCARH143

NCT03338972: Phase 1 - Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma


This phase I trial studies the side effects and best dose of BCMA CAR-T cells in treating patients with BCMA positive multiple myeloma that has come back or does not respond to treatment. T cells are a type of white blood cell and a major component of the immune system. T-cells that have been genetically modified in the laboratory express BCMA and may kill cancer cells with the protein BCMA on their surface. Giving chemotherapy before BCMA CAR-T cells may reduce the amount of disease and to cause a low lymphocyte (white blood cell) count in the blood, which may help the infused BCMA CAR-T cells survive and expand.


Sponsor

Fred Hutchinson Cancer Research Center


Collaborators

Juno Therapeutics, Inc.

National Cancer Institute (NCI)

 

ClinicalTrials.gov Identifier: NCT03338972

A Phase I Study of Adoptive Immunotherapy for Advanced B-Cell Maturation Antigen (BCMA)+ Multiple Myeloma With Autologous CD4+ and CD8+ T Cells Engineered to Express a BCMA-Specific Chimeric Antigen Receptor

First Posted : November 9, 2017


Click here for details on ClinicalTrials.gov

 

Biological: Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143

Drug: Cyclophosphamide

Drug: Fludarabine

Other: Laboratory Biomarker Analysis

Procedure: Leukapheresis

 

Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143

autologous anti-BCMA-CAR-expressing CD4+/CD8+ T lymphocytes FCARH143

autologous anti-BCMA-CAR CD4+/CD8+ cells

BCMA CAR-CD4+/CD8+ T cells

BCMA-specific CAR-expressing CD4+/CD8+ T lymphocytes

FCARH143


A preparation of ex vivo expanded autologous CD8+ and CD4+ T cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities

 

653.Myeloma: Therapy, excluding Transplantation| November 13, 2019

Response to Bcma CAR-T Cells Correlates with Pretreatment Target Antigen Density and Is Improved By Small Molecule Inhibition of Gamma Secretase


https://doi.org/10.1182/blood-2019-129582

 

- Washington: Fred Hutchinson Cancer Center Seattle

 

Location

United States, Washington

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