• Recruiting

NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Cancer

RRMM

Relapsed Refractory Multiple Myeloma


NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

KPT-8602

NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications


This is a first-in-human, multi-center, open-label clinical study with separate dose escalation (Phase 1) and expansion (Phase 2) stages to assess preliminary safety, tolerability, and efficacy of the second generation oral XPO1 inhibitor KPT-8602 in participants with relapsed/refractory multiple myeloma (MM), metastatic colorectal cancer (mCRC), metastatic castration resistant prostate cancer (mCRPC), higher risk myelodysplastic syndrome (HRMDS), acute myeloid leukemia (AML) and newly diagnosed intermediate/high-risk MDS.


Sponsor

Karyopharm Therapeutics Inc

 

ClinicalTrials.gov Identifier: NCT02649790

Official Title:A Phase 1/2 Open-Label Study of the Safety, Tolerability and Efficacy of the Selective Inhibitor of Nuclear Export (SINE) Compound Eltanexor (KPT-8602) in Patients With Newly Diagnosed and Relapsed/Refractory Cancer Indications

First Posted : January 7, 2016

Click here to see details on ClinicalTrials.gov

 

KPT-8602

Eltanexor (Code C125193)

(2E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)prop-2-enamide

ATG 016

ATG-016

ATG016

Eltanexor

ELTANEXOR

Exportin 1 Inhibitor KPT-8602

KPT-8602

Selective Inhibitor of Nuclear Export KPT-8602

XPO1-inhibiting SINE Compound KPT-8602


ASTX727

Decitabine and Cedazuridine (Code C115102)

ASTX727

C-DEC

CDA Inhibitor E7727/Decitabine Combination Agent ASTX727

Cedazuridine/Decitabine Combination Agent ASTX727

Cedazuridine/Decitabine Tablet

DEC-C

Decitabine and Cedazuridine

Inqovi

 

Drug: KPT-8602

Drug: ASTX727

Drug: Dexamethasone

 

Locations

United States, California

United States, Colorado

United States, Florida

United States, Michigan

United States, Missouri

United States, Nebraska

United States, New Jersey

United States, New Mexico

United States, New York

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United States, Tennessee

United States, Texas

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United States, Virginia

United States, Washington

Canada, Ontario

Canada, Quebec

China, Tianjin

Europe

Spain

France


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