NCT05024045: Phase 1 - Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

• NCT05024045: Phase 1 - Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

The purpose of this study is to find out whether the study drug, LOXO-338, is safe and effective in patients with advanced blood cancer. Patients must have already received standard therapy. The study may last up to approximately 3 years.

Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoma, B-cell Marginal Zone

Lymphoma, Non-Hodgkin

Multiple Myeloma

B-cell Lymphoma

Waldenstrom Macroglobulinemia

Lymphoma, Mantle-Cell

Sponsor

Eli Lilly and Company

Collaborator

Loxo Oncology, Inc

Multiple Locations

International Study

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ClinicalTrials.gov Identifier: NCT05024045

Official Title: A Phase 1 Study of Oral LOXO-338, a Selective BCL-2 Inhibitor, in Patients With Advanced Hematologic Malignancies

First Posted : August 27, 2021

Click here for details on ClinicalTrials.gov

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Drug: LOXO-338

Bcl-2 inhibitor LOXO-338

Drug: Pirtobrutinib

BTK inhibitor LOXO-305

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Drug: LOXO-338

Bcl-2 inhibitor LOXO-338

Drug: Pirtobrutinib

BTK inhibitor LOXO-305

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Locations

United States, Florida

United States, Indiana

United States, Kansas

United States, Minnesota

United States, New York

United States, Washington

United States, Wisconsin

Europe

France

Poland

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