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NCT01816971: Phase 2 - Carfilzomib, Lenalidomide, and Dexamethasone Before and After ASCT NDMM

Updated: Aug 9, 2022

Carfilzomib, Lenalidomide, and Dexamethasone Before and After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma


Open-label, Single-arm, Phase 2 Study of the Initial and Post-Transplant Treatment With Carfilzomib, Lenalidomide and Low Dose Dexamethasone (CRd) in Transplant Candidates With Newly Diagnosed, Multiple Myeloma Requiring Systemic Chemotherapy


KRd


This phase II trial studies how well carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant works in treating patients with newly diagnosed multiple myeloma. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from diving. Giving carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant may kill more cancer cells


Sponsor

University of Chicago


Collaborator

National Cancer Institute (NCI)

 

ClinicalTrials.gov Identifier: NCT01816971

Official Title: Open-label, Single-arm, Phase 2 Study of the Initial and Post-Transplant Treatment With Carfilzomib, Lenalidomide and Low Dose Dexamethasone (CRd) in Transplant Candidates With Newly Diagnosed, Multiple Myeloma Requiring Systemic Chemotherapy

First Posted: March 22, 2013


Click here to see details on ClinicalTrials.gov

 


 

Blood; 2020 Nov


Blood Cancer J; 2021 Feb

 

Drug: dexamethasone

Drug: carfilzomib

Drug: lenalidomide

Procedure: autologous hematopoietic stem cell transplantation

Other: laboratory biomarker analysis

 

Locations

United States, Illinois

United States, Massachusetts

United States, Missouri

United States, Tennessee

Canada, Ontario


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