top of page
  • Not yet recruiting

NCT06158841: Phase 3: Intravenous (IV) ABBV-383 Monotherapy Versus Standard Therapies Relapsed/Refractory Myeloma

Updated: Feb 20

  • NCT06158841: Phase 3: Intravenous (IV) ABBV-383 Monotherapy Versus Standard Therapies RRMM

  • Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma



abbv 383 phase 3 trial

ABBV-383 is an investigational drug being developed for the treatment of R/R MM. This study is broken into 2 Arms; Arm A and Arm B. . In Arm A, participants will receive ABBV-383 as a monotherapy. In Arm B, participants will receive the standard available therapy (SAT) identified by the Investigator during screening, in accordance with the local (or applicable) approved label, package insert, summary of product characteristics, and/or the institutional guidelines, as applicable. Around 380 adult participants with relapsed/refractory multiple myeloma will be enrolled at approximately 140 sites across the world.



ABBV-383 - Participants will receive ABBV-383 as a monotherapy.


Standard Available Therapy (SAT) - SAT choices are carfilzomib + dexamethasone (Kd), elotuzumab + pomalidomide + dexamethasone (EloPd), selinexor + bortezomib + dexamethasone (SVd).


Sponsor


Multiple Locations

 

ClinicalTrials.gov Identifier: NCT06158841


Official Title: A Phase 3, Multicenter, Randomized, Open Label Study of ABBV-383 Compared With Standard Available Therapies in Subjects With Relapsed or Refractory Multiple Myeloma (3L+ RRMM Monotherapy Study)


First Posted : December 6, 2023


Click here to see details on ClinicalTrials.gov

 

Drug: ABBV-383

Drug: Carfilzomib

Drug: Pomalidomide

Drug: Elotuzumab

Drug: Selinexor

Drug: Bortezomib

Drug: Dexamethasone


ABBV-383 (formerly TNB-383B)

anti-alpha BCMA/anti-alpha CD3 T-cell engaging bispecific antibody TNB-383B

 

* TNB-383B

* anti-BCMA x aCD3 T-BsAb TNB-383B

* anti-BCMA x aCD3 T-cell engaging bispecific antibody TNB-383B

 

Locations

Multiple





Comments


Commenting has been turned off.
Posts Archive
bottom of page