• Recruiting

NCT04136756: Phase 1 - NKTR-255 in Relapsed/Refractory Multiple Myeloma & Non-Hodgkin Lymphoma

Updated: May 26


NCT04136756: Phase 1 - NKTR-255 in Relapsed/Refractory Multiple Myeloma & Non-Hodgkin Lymphoma

NKTR-255


NKTR-255 in Relapsed/Refractory Multiple Myeloma & Non-Hodgkin Lymphoma


Patients will receive intravenous (IV) NKTR-255 in 21 or 28 day treatment cycles. During the Part 1 dose escalation portion of the trial, patients will either receive NKTR-255 as monotherapy, NKTR-255 administered as a doublet with daratumumab subcutaneous (DARZALEX FASPRO TM), or NKTR-255 administered as a doublet with rituximab. After determination of the recommended Phase 2 dose (RP2D) of NKTR-255, NKTR-255 will be evaluated in Part 2. During the Part 2 dose expansion portion of the trial, patients will either receive NKTR-255 as monotherapy, NKTR-255 administered as a doublet with daratumumab subcutaneous (DARZALEX FASPRO TM), or NKTR-255 administered as a doublet with rituximab.


This is a Phase 1 study to evaluate safety and tolerability of NKTR-255 alone and in combination with daratumumab or rituximab.


Sponsor

Nektar Therapeutics

 

ClinicalTrials.gov Identifier: NCT04136756


Official Title: A Phase 1, Open-label, Multi-center, Dose Escalation and Dose Expansion Study of NKTR-255 in Relapsed or Refractory Hematological Malignancies


First Posted : October 23, 2019


Click here to see details on ClinicalTrials.gov

NKTR-255 in Relapsed / Refractory Multiple Myeloma & Non-Hodgkin Lymphoma

 

Drug: NKTR-255

Drug: NKTR-255 Q21

Drug: Rituximab

Drug: Daratumumab

 

NKTR 255

Polymer-conjugated IL-15 Receptor Agonist NKTR-255 (Code C165666)

IL-15 Receptor Agonist NKTR-255

Long-acting Polymer-engineered IL-15 Conjugate NKTR-255

NKTR 255

NKTR-255

NKTR255

Polymer-conjugated IL-15 Receptor Agonist NKTR-255

 

Phase I study protocol: NKTR-255 as monotherapy or combined with daratumumab or rituximab in hematologic malignancies


Future Oncol;. 2021 Sep

https://pubmed.ncbi.nlm.nih.gov/34154392/

 

Locations

United States, Arizona

United States, California

United States, Florida

United States, Georgia

United States, Illinois

United States, Michigan

United States, Minnesota

United States, New York

United States, North Carolina

United States, Texas

United States, Virginia

United States, Washington


Posts Archive