What are Multiple myeloma defining events? International Myeloma Working Group - SLiM-CRAB Criteria
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- Jun 11, 2021
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Updated: Jun 23, 2022
What are Multiple myeloma defining events? International Myeloma Working Group - SLiM-CRAB Criteria
What are myeloma defining events? The SLiM-CRAB Criteria
International Myeloma Working Group (IMWG) diagnostic criteria for MM
END ORGAN DAMAGE
C = increased calcium levels (greater than 11.5 mg/dL
R = renal insufficiency (creatinine greater than 2 mg/dL or creatinine clearance less than 40 mL/min
A = anemia (hemoglobin less than 10 g/dL or 2 g/dL less than normal
B = presence of bone lesions ( presence of one or more osteolytic lesions seen on skeletal radiography, whole-body MRI, or whole-body FDG PET/CT )
MM DEFINING BIOMARKERS
S = greater than or equal to sixty percent clonal plasma cells in the bone marrow
Li = involved/uninvolved free light chain ratio of 100 or more with the involved FLC being greater than or equal 100 mg/L
M = MRI with more than one focal marrow lesion
Reference:
Updated Diagnostic Criteria and Staging System for Multiple Myeloma - Am Soc Clin Oncol Educ Book; 2016
https://pubmed.ncbi.nlm.nih.gov/27249749/
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