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NCT05139225: Phase 1: A Study of TTI-621 and TTI-622 in Combination With Daratumumab RRMM

Updated: Jun 27

NCT05139225: Phase 1: A Study of TTI-621 and TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma


TTI-621 - Trillium

A Study of TTI-621 and TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma


This study will test the safety of TTI-621 or TTI-622 in combination with daratumumab hyaluronidase-fihj in people with relapsed/refractory multiple myeloma. The researchers look for the highest dose of TTI-621 and TTI-622 that causes few or mild side effects in participants when given in combination with daratumumab hyaluronidase-fihj. Once the researchers find the highest safe dose of each study drug, they will further test the combinations (TTI-621 + daratumumab hyaluronidase-fihj and TTI-622 + daratumumab hyaluronidase-fihj) in new participants to find out if the combinations are effective in treating relapsed/refractory multiple myeloma. Researchers think that combining TTI-621 or TTI-622 with daratumumab hyaluronidase-fihj, a standard treatment for multiple myeloma, may be an effective treatment approach.


Sponsor

Memorial Sloan Kettering Cancer Center


Collaborator

Trillium Therapeutics Inc.

 

ClinicalTrials.gov Identifier: NCT05139225


A Phase Ib Study Of The Combination Of CD47 Blockade With SIRP-Alpha FC Fusion Proteins (TTI-621 Or TTI-622) And Daratumumab Hyaluronidase-fihj For Patients With Relapsed or Refractory Multiple Myeloma


First Posted : December 1, 2021


Click here to see details on ClinicalTrials.gov

 

Drug: TTI-621

Drug: TTI-622

Drug: Daratumumab Hyaluronidase-fihj

 

TTI 621

Ontorpacept (Code C125718)

Ontorpacept

ONTORPACEPT

SIRPa-Fc Fusion Protein TTI-621

SIRPaFc

TTI 621

TTI-621


TTI 622

SIRPa-IgG4-Fc Fusion Protein TTI-622 (Code C150756)

SIRPa-IgG4 Fc

SIRPa-IgG4 Fc TTI-622

SIRPa-IgG4-Fc Fusion Protein TTI-622

TTI 622

TTI-622

TTI622

 

Locations:

United States, New Jersey

United States, New York

 

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