• Completed

NCT02546167: Phase 1 - CART-BCMA Cells for Multiple Myeloma

Updated: Apr 26

NCT02546167: Phase 1 - CART-BCMA Cells for Multiple Myeloma


UPENN-CART

Open-label, single-center, pilot study to assess the safety and feasibility of infusion of autologous T cells expressing BCMA (B-cell maturation antigen)-specific chimeric antigen receptors with tandem TCR and 4-1BB costimulatory domains (referred to as CART-BCMA ) in adult patients with multiple myeloma (MM). CART-BCMA cells will be given as a split dose intravenous infusion over 3 days. The duration of active intervention and monitoring is approximately 2 years.


Sponsor: University of Pennsylvania


ClinicalTrials.gov Identifier: NCT02546167


Pilot Study Of Redirected Autologous T Cells Engineered To Contain an Anti-BCMA scFv Coupled To TCRζ And 4-1BB Signaling Domains in Patients With Relapsed and/or Refractory Multiple Myeloma


Click here for details on Clinicaltrials.gov

 

CART - BCMA : National Cancer Institute

autologous anti-BCMA-CAR-TCRz/4-1BB-expressing T lymphocytes CART-BCMA

autologous BCMA 4-1BBz CAR T cells CART-BCMA

autologous BCMA-specific CAR-TCRz/4-1BB-expressing T lymphocytes CART-BCMA

CART-BCMA cells

CART-BCMA

 

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.

J Clin Invest. 2019


Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma.

Oncotarget. 2018

 

- PennsylvaniaL Abramson Cancer Center of the University of Pennsylvania Philadelphia




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