• Recruiting

NCT04394650: Phase 1 - CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in RRMM

Updated: Sep 2

CC-98633 CART

CC-98633

NCT04394650: Phase 1 - A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma


This is a Phase 1, multicenter, open-label study of CC-98633, BCMA-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in subjects with relapsed and/or refractory multiple myeloma.

The study will consist of 2 parts: dose-escalation (Part A) and dose-expansion (Part B). The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at the RP2D.


Sponsor

Juno Therapeutics, a Subsidiary of Celgene

 

ClinicalTrials.gov Identifier: NCT04394650


A Phase I, Multi Center, Open Label Study of CC-98633, BCMA Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma


First Posted : May 19, 2020


Click here for details on ClinicalTrials.gov

 

CC 98633

Autologous BCMA-targeted CAR T Cells CC-98633 (Code C173699)

Autologous BCMA-targeted CAR T Cells CC-98633

Autologous BCMA-targeted CAR T-cells CC-98633

Autologous BCMA-targeted NEX-T CAR T Cells CC-98633

CC 98633

CC-98633

CC98633

 

CART

Biological: CC-98633

Autologous BCMA-targeted CAR T Cells CC-98633

 

- Multiple locations

- Alabama: University of Alabama at Birmingham

- California: Stanford Cancer Center

- New York: Roswell Park Cancer Institute Buffalo

- New York: Tisch Cancer Institute Mount Sinai Hospital New York

- New York: Memorial Sloan-Kettering Cancer Center New York

- Arizona: Mayo Clinic Arizona

- Illinois: University of Chicago

- Minnesota: Mayo Clinic Rochester Minnesota

- North Carolina: Levine Cancer Institute Charlotte

- Texas: UT Southwestern Medical Center Dallas

 

Locations

United States, Alabama

United States, Arizona

United States, California

United States, Illinois

United States, Kansas

United States, Minnesota

United States, New York

United States, North Carolina

United States, Texas




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