NCT04394650: Phase 1 - CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in RRMM

• CC-98633 CART

NCT04394650: Phase 1 - A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma

This is a Phase 1, multicenter, open-label study of CC-98633, BCMA-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in subjects with relapsed and/or refractory multiple myeloma.

The study will consist of 2 parts: dose-escalation (Part A) and dose-expansion (Part B). The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at the RP2D.

Sponsor

Juno Therapeutics, a Subsidiary of Celgene

---

ClinicalTrials.gov Identifier: NCT04394650

A Phase I, Multi Center, Open Label Study of CC-98633, BCMA Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma

First Posted : May 19, 2020

Click here for details on ClinicalTrials.gov

---

CC 98633

Autologous BCMA-targeted CAR T Cells CC-98633 (Code C173699)

Autologous BCMA-targeted CAR T Cells CC-98633

Autologous BCMA-targeted CAR T-cells CC-98633

Autologous BCMA-targeted NEX-T CAR T Cells CC-98633

CC 98633

CC-98633

CC98633

---

CART

Biological: CC-98633

Autologous BCMA-targeted CAR T Cells CC-98633

---

- Multiple locations

- Alabama: University of Alabama at Birmingham

- California: Stanford Cancer Center

- New York: Roswell Park Cancer Institute Buffalo

- New York: Tisch Cancer Institute Mount Sinai Hospital New York

- New York: Memorial Sloan-Kettering Cancer Center New York

- Arizona: Mayo Clinic Arizona

- Illinois: University of Chicago

- Minnesota: Mayo Clinic Rochester Minnesota

- North Carolina: Levine Cancer Institute Charlotte

- Texas: UT Southwestern Medical Center Dallas

---

Locations

United States, Alabama

United States, Arizona

United States, California

United States, Illinois

United States, Kansas

United States, Minnesota

United States, New York

United States, North Carolina

United States, Texas