NCT04934475: Phase 3 - IFM 2020-02 Minimal Residual Disease Adapted Strategy (MIDAS) KRD-Isatuximab

IFM 2020-02

MInimal Residual Disease Adapted Strategy (MIDAS)

Isa-KRd

NCT04934475: Phase 3 - IFM 2020-02 -MInimal Residual Disease Adapted Strategy (MIDAS) - KRD-Isatuximab

IFM 2020-02 will enroll patients eligible for ASCT less than 66 years. All patients will receive induction based on 6 cycles (28-day) of KRD-Isatuximab (Isa-KRD), in order to achieve deep responses and high MRD negativity rates. Patients will be classified at diagnosis according to cytogenetics (standard vs high-risk cytogenetics defined by the LP score including 17p deletion, t(4;14), del(1p32), gain 1q, trisomy 21 and trisomy 5).

Sponsor

Intergroupe Francophone du Myelome

Collaborators

Amgen

Sanofi

Bristol-Myers Squibb