- Active, not recruiting
NCT03180736 : Phase 3 - EMN 14 - Pomalidomide and Dexa +/- Dara in relapsed MM - APOLLO study
Updated: Sep 25, 2022
The APOLLO study
EMN14/54767414MMY3013
Comparison of Pomalidomide and Dexamethasone With or Without Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Previously Treated With Lenalidomide and a Proteasome InhibitorDaratumumab/Pomalidomide/Dexamethasone vs Pomalidomide/Dexamethasone (EMN14)
The purpose of this study is to evaluate the effects of the addition of daratumumab to pomalidomide and dexamethasone in terms of progression-free survival in subjects with relapsed or refractory Multiple Myeloma.
Comparison of Pomalidomide and Dexamethasone With or Without Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Previously Treated With Lenalidomide and a Proteasome Inhibitor Daratumumab/Pomalidomide/Dexamethasone vs Pomalidomide/Dexamethasone (EMN14)
Sponsor
Collaborator
Janssen Research & Development, LLC
ClinicalTrials.gov Identifier: NCT03180736
Official Title: A Phase 3 Study Comparing Pomalidomide and Dexamethasone With or Without Daratumumab in Subjects With Relapsed or Refractory Multiple Myeloma Who Have Received at Least One Prior Line of Therapy With Both Lenalidomide and a Proteasome Inhibitor.
First Posted : June 8, 2017
Click here to see details on ClinicalTrials.gov
EMN14 - European Myeloma Network (myeloma-europe.org)
Daratumumab : National Cancer Institute
Daratumumab : MedlinePlus Drug Information
Daratumumab and Hyaluronidase-fihj Injection: National Cancer Institute
Daratumumab and Hyaluronidase-fihj Injection: MedlinePlus Drug Information
Dexamethasone : National Cancer Institute
Dexamethasone : MedlinePlus Drug Information
Pomalidomide: National Cancer Institute
Pomalidomide : MedlinePlus Drug Information
Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial
PMID: 34087126; Lancet Oncol; June 2021
Click here to see details.
ASH 2020 Annual Meeting - APOLLO Oral Presentation
412 Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Click here to see details.
Drug: Daratumumab
Drug: Pomalidomide
Drug: Dexamethasone
Locations:
Europe
Belgium
Czechia
Denmark
Germany
Greece
Italy
Netherlands
Serbia
Spain
Turkey