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  • Active, not recruiting

NCT04108195: Phase 1b - Subcutaneous Dara With Bispecific T Cell Redirection Antibodies - TRIMM-2

Updated: Feb 10

  • TRIMM-2 study


  • A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma


  • JNJ 64007957 - Teclistamab (A bispecific humanized monoclonal antibody BCMA*CD3)

  • JNJ-64407564 - Talquetamab (A bispecific humanized monoclonal antibody GPRC5D*CD3)


trimm2

The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.


A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma


Daratumumab (Darzalex)

Pomalidomide ( Pomalyst)

Teclistamab (JNJ 64007957)

Talquetamab (JNJ-64407564)


Sponsor


Multiple Locations

International Study

 

ClinicalTrials.gov Identifier: NCT04108195

Official Title: A Phase 1b Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Subjects With Multiple Myeloma

First Posted : September 30, 2019

Click here for details on ClinicalTrials.gov

 


 

Drug: Daratumumab

Drug: Talquetamab

Drug: Teclistamab

Drug: Pomalidomide

 

Blood Adv; 2020

Teclistamab is an active T cell-redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

 

161 Phase 1b Results for Subcutaneous Talquetamab Plus Daratumumab in Patients with Relapsed/Refractory Multiple Myeloma

Program: Oral and Poster Abstracts

Type: Oral

Session: 653. Myeloma and Plasma Cell Dyscrasias: Clinical-Prospective Therapeutic Trials: Novel Targets and Amyloid

Hematology Disease Topics & Pathways:

Clinical Trials, Biological, Bispecific Antibody Therapy, Clinical Research, Plasma Cell Disorders, Diseases, Therapies, Immunotherapy, Lymphoid Malignancies

Saturday, December 11, 2021: 1:00 PM


 

1647 Subcutaneous Teclistamab in Combination with Daratumumab for the Treatment of Patients with Relapsed/Refractory Multiple Myeloma: Results from a Phase 1b Multicohort Study

Program: Oral and Poster Abstracts

Session: 653. Myeloma and Plasma Cell Dyscrasias: Clinical-Prospective Therapeutic Trials: Poster I

Hematology Disease Topics & Pathways:

Clinical Trials, Biological, Bispecific Antibody Therapy, Plasma Cell Disorders, Clinical Research, Diseases, Therapies, Immunotherapy, Lymphoid Malignancies

Saturday, December 11, 2021, 5:30 PM-7:30 PM


 

RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.


Results from the TRiMM-2 study of talquetamab (Abstract #161) and teclistamab (Abstract #1647) in combination with DARZALEX FASPRO®(daratumumab and hyaluronidase-fihj)will also be presented.


 

EHA 2022 Oral Presentations

EHA 2022 - HYBRID - JUNE 9-17 - VIENNA

NOVEL COMBINATION IMMUNOTHERAPY FOR THE TREATMENT OF RELAPSED/REFRACTORY MULTIPLE MYELOMA: UPDATED PHASE 1B RESULTS FOR TALQUETAMAB (A GPRC5D X CD3 BISPECIFIC ANTIBODY) IN COMBINATION WITH DARATUMUMAB


 

- California: University of California San Francisco

- California: City of Hope Duarte

- New York: Tisch Cancer Institute Mount Sinai Hospital New York

- North Carolina: Levine Cancer Institute Charlotte

- Pennsylvania: University of Pennsylvania Philadelphia

- North Carolina: Wake Forest Baptist Health Winston-Salem

 

Locations

United States, California

United States, New York

United States, North Carolina

United States, Pennsylvania

United States, Tennessee

United States, Wisconsin


Canada, Alberta

Canada, British Columbia

Canada, Ontario


Europe

Germany

Netherlands

Spain

 

RELATED POSTS

TECLISTAMAB STUDIES:


NCT03145181: Phase 1 - Teclistamab, Humanized BCMA*CD3 Bispecific Ab, in Relapsed Myeloma (MajesTEC1)


NCT04557098: Phase 2- Teclistamab, in Participants With Relapsed or Refractory Myeloma (MajesTEC-1)


NCT05083169: Phase 3 - Tec-Dara Vs DPd Vs DVd in Relapsed or Refractory Myeloma - (MajesTEC-3)


NCT05243797: Phase 3: Tec + Len Vs Len Alone in NDMM as Maintenance Therapy Post ASCT (MajesTEC-4)


NCT04722146: Phase 1b - Teclistamab With Other Anticancer Therapies in Participants With Myeloma


NCT05231629: Phase 2: Sequential Therapy in Multiple Myeloma Guided by MRD Assessments (MASTER-2)

 

TALQUETAMAB STUDIES:


NCT03399799: Phase 1 - Talquetamab, a Humanized GPRC5D x CD3 Bis Ab - Ref MM - MonumenTAL-1


NCT04634552: Phase 2 - A Study of Talquetamab in Participants With Refractory Multiple Myeloma


NCT05050097: Phase 1 - A Study of Talquetamab With Other Anticancer Therapies in Multiple Myeloma


NCT04773522: Phase 1 - JNJ-64407564 in Japanese Participants With Relapsed or Refractory Myeloma

 

TECLISTAMAB AND TALQUETAMAB STUDIES:


NCT04586426: Phase 1b - Talquetamab and Teclistamab in Relapsed or Refractory Multiple Myeloma



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