• Active, not recruiting

NCT04181827: Phase 3 -Cilta-cel vs Pom/Bort/Dex or Dara/Pom/Dex in relpsd. len ref MM CARTITUDE 4

Updated: Oct 3

CARTITUDE-4

Ciltacabtagene Autoleucel

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4)

CARTITUDE-4

The purpose of this study is to compare the efficacy of JNJ-68284528 (ciltacabtagene autoleucel [cilta-cel]) with standard therapy, either Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd).


A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4)


Sponsor

Janssen Research & Development, LLC


Legend Biotech

 

ClinicalTrials.gov Identifier: NCT04181827

Official Title: A Phase 3 Randomized Study Comparing JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA, Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Subjects With Relapsed and Lenalidomide-Refractory Multiple Myeloma

First Posted : December 2, 2019

Click here for details on ClinicalTrials.gov

 

CART - BCMA : National Cancer Institute

CART

 

Cilta-cel

Ciltacabtagene Autoleucel (Code C148498)

Autologous Anti-BCMA CAR-T Cells JNJ-68284528

Autologous Bi-epitope BCMA-targeted CAR T-cells JNJ-68284528

Autologous Bi-epitope CAR T-cells JNJ-68284528

Cilta-cel

Ciltacabtagene Autoleucel

CILTACABTAGENE AUTOLEUCEL

JNJ-68284528

LCAR-B38M

LCAR-B38M-transduced CAR-T Cells JNJ-68284528

LCAR-B38M-transduced Car-T Cells JNJ-68284528

Carvykti

 

3866 Efficacy and Safety of Ciltacabtagene Autoleucel (Cilta-cel), a B-Cell Maturation Antigen (BCMA)–Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Lenalidomide-Refractory Patients with Progressive Multiple Myeloma after 1–3 Prior Lines of Therapy: Updated Results from CARTITUDE-2

Program: Oral and Poster Abstracts

Session: 704. Cellular Immunotherapies: Clinical: Poster III

Hematology Disease Topics & Pathways:

Biological, Clinical Trials, Plasma Cell Disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Clinical Research, Diseases, Therapies, Infusion, Lymphoid Malignancies

Monday, December 13, 2021, 6:00 PM-8:00 PM


Click here for details

 

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