• Recruiting

NCT04126200: Phase 1/2 - Belantamab Mafodotin as Monotherapy & With Anti-cancer Rx (RRMM) (DREAMM 5)

Updated: Oct 24

DREAMM 5


Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 5)

DREAMM 5 BELANTAMAB

B-cell maturation antigen (BCMA) is a target present on tumor cells in participants with multiple myeloma. Belantamab mafodotin (GSK2857916); is an antibody-drug conjugate (ADC) containing humanized anti-BCMA monoclonal antibody (mAb). This is a phase I/II, randomized, open-label, platform study designed to evaluate the effects of belantamab mafodotin in combination with other anti-cancer drugs in participants with relapsed/refractory multiple myeloma. The Platform design incorporates a single master protocol, where multiple treatment combinations, as sub-studies, will be evaluated simultaneously.


Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 5)


Sponsor

GlaxoSmithKline

 

ClinicalTrials.gov Identifier: NCT04126200 Official Title: A Phase I/II, Randomized, Open-label Platform Study Utilizing a Master Protocol to Study Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Anti-Cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) - DREAMM 5

First Posted : October 15, 2019

Click here for details on ClinicalTrials.gov


DREAMM Clinical Trial Program (dreammtrials.com)

 

Belantamab mafodotin : National Cancer Institute

Belantamab mafodotin : MedlinePlus Drug Information

GSK2857916


Drug: Belantamab mafodotin

Drug: GSK3174998

Drug: Feladilimab

Drug: Nirogacestat

Drug: Dostarlimab

Drug: Isatuximab

 

Nirogacestat

Nirogacestat (Code C82383)

Nirogacestat

NIROGACESTAT

PF-03084014

gamma secretase inhibitor PF-03084014

 

Feladilimab

Anti-ICOS Agonist Antibody GSK3359609

Feladilimab

FELADILIMAB

GSK3359609


Dostarlimab

ANB011

Dostarlimab

DOSTARLIMAB

Dostarlimab-gxly

Immunoglobulin G4, Anti-programmed Cell Death Protein 1 (PDCD1) (Humanized Clone ABT1 Gamma4-chain), Disulfide with Humanized Clone ABT1 Kappa-chain, Dimer

Jemperli

TSR 042

TSR-042

TSR042


Anti-OX40 Monoclonal Antibody GSK3174998 (Code C124783)

Anti-OX40 Monoclonal Antibody GSK3174998

GSK-3174998

GSK3174998

 

Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design.

Future Oncol. 2021 Jun

 

897 DREAMM-5 Study: Investigating the Synergetic Effects of Belantamab Mafodotin Plus Inducible T-Cell Co-Stimulator Agonist (aICOS) Combination Therapy in Patients with Relapsed/Refractory Multiple Myeloma

Program: Oral and Poster Abstracts

Type: Oral

Session: 653. Myeloma and Plasma Cell Dyscrasias: Clinical-Prospective Therapeutic Trials: Immune Therapy for Multiple Myeloma

Hematology Disease Topics & Pathways:

Clinical Trials, Antibody Therapy, Biological, Clinical Research, Plasma Cell Disorders, Diseases, Therapies, Lymphoid Malignancies, Monoclonal Antibody Therapy

Monday, December 13, 2021: 6:45 PM


Learn more

 

GSK showcases progress from the DREAMM clinical trial programme in multiple myeloma at the 2021 ASH Annual Meeting

18 November 2021: Issued: London UK

Data demonstrate potential of Blenrep (belantamab mafodotin-blmf) in combination with standard of care therapies in patients with newly diagnosed and relapsed/refractory multiple myeloma

GlaxoSmithKline (GSK) plc today announced 11 abstracts on Blenrep (belantamab mafodotin-blmf) will be presented at the upcoming American Society of Hematology (ASH) Annual Meeting and Exposition, to be hosted in Atlanta, Georgia, US and virtually from 11-14 December 2021. Presentations include updates from the DREAMM (DRiving Excellence in Approaches to Multiple Myeloma) clinical trial programme and two collaborative studies that will demonstrate the potential of belantamab mafodotin, a first-in-class anti-BCMA (B-cell maturation antigen) therapy, in multiple myeloma.


Learn more:

https://www.gsk.com/en-gb/media/press-releases/gsk-showcases-progress-from-the-dreamm-clinical-trial-programme-in-multiple-myeloma-at-the-2021-ash-annual-meeting/

 

Synergistic effects of low-dose belantamab mafodotin in combination with a gamma-secretase inhibitor (nirogacestat) in patients with relapsed/refractory multiple myeloma (RRMM): DREAMM-5 study.

2022 ASCO Annual Meeting

June 02, 2022

Click here for details

 

(12) DREAMM-5 Study of BLENREP (belantamab mafodotin) Combined with Nirogacestat in RRMM patients - YouTube

June 29, 2022

International Myeloma Foundation

Subscribe to our channel: https://www.youtube.com/c/IMFMyeloma

 

- Massachusetts: Dana-Farber Cancer Institute/Harvard Cancer Center Boston

 

Locations

United States, Georgia

United States, Indiana

United States, Massachusetts

United States, Michigan

United States, Texas

United States, Wisconsin

Canada, British Columbia

Canada, Nova Scotia

Canada, Ontario

Australia, Victoria

Europe

France

Germany

Netherlands

Spain

Greece

Norway

Poland

Sweden

Asia

Korea, Republic of

Russian Federation

 

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