NCT02465060: Phase 2: Targeted Therapy Directed by Genetic Testing in Treating Patients With RRMM

NCT02465060: phase 2: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.

Sponsor

National Cancer Institute (NCI)

ECOG-ACRIN Cancer Research Group

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ClinicalTrials.gov Identifier: NCT02465060

Official Title: Molecular Analysis for Therapy Choice (MATCH)

First Posted: June 8, 2015

Click here for details on ClinicalTrials.gov

EAY131 / NCI MATCH Home Page - ECOG-ACRIN Cancer Research Group

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Drug: Adavosertib

Definition of adavosertib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Afatinib

Drug: Afatinib Dimaleate

Definition of afatinib dimaleate - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Binimetinib

Definition of binimetinib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Capivasertib

Definition of capivasertib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Copanlisib

Definition of copanlisib hydrochloride - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Copanlisib Hydrochloride

Definition of copanlisib hydrochloride - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Crizotinib

Definition of crizotinib - NCI Drug Dictionary - NCI (cancer.gov)

Other: Cytology Specimen Collection Procedure

Drug: Dabrafenib

Definition of dabrafenib mesylate - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Dabrafenib Mesylate

Definition of dabrafenib mesylate - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Dasatinib

Definition of dasatinib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Defactinib

Definition of defactinib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Defactinib Hydrochloride

Drug: Erdafitinib

Definition of erdafitinib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: FGFR Inhibitor AZD4547

Definition of FGFR inhibitor AZD4547 - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Ipatasertib

Definition of ipatasertib - NCI Drug Dictionary - NCI (cancer.gov)

Other: Laboratory Biomarker Analysis

Drug: Larotrectinib

Drug: Larotrectinib Sulfate

Definition of larotrectinib sulfate - NCI Drug Dictionary - NCI (cancer.gov)

Biological: Nivolumab

Definition of nivolumab - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Osimertinib

Definition of osimertinib mesylate - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Palbociclib

Definition of palbociclib - NCI Drug Dictionary - NCI (cancer.gov)

Biological: Pertuzumab

Definition of pertuzumab - NCI Drug Dictionary - NCI (cancer.gov)

Drug: PI3K-beta Inhibitor GSK2636771

Definition of PI3K-beta inhibitor GSK2636771 - NCI Drug Dictionary - NCI (cancer.gov)

Biological: Relatlimab

Definition of relatlimab - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Sapanisertib

Definition of sapanisertib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Sunitinib Malate

Definition of sunitinib malate - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Taselisib

Definition of taselisib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Trametinib

Biological: Trastuzumab

Definition of trastuzumab - NCI Drug Dictionary - NCI (cancer.gov)

Biological: Trastuzumab Emtansine

Definition of ado trastuzumab emtansine - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Ulixertinib

Definition of ulixertinib - NCI Drug Dictionary - NCI (cancer.gov)

Drug: Vismodegib

Definition of vismodegib - NCI Drug Dictionary - NCI (cancer.gov)

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