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NCT03941860: Phase 3 - EAA171 - OPTIMUM - Addition of Ixazomib to Lenalidomide in Residual Myeloma

Updated: Feb 10


  • EAA171

  • OPTIMUM

  • NCT03941860: Testing the Addition of Ixazomib to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM Trial


EAA171 optimum myeloma study ecog acrin

Testing the Addition of Ixazomib to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM Trial

NCT03941860: Phase 3 - Addition of Ixazomib to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM Trial


This phase III trial studies how well lenalidomide in combination with ixazomib works compared to lenalidomide alone in treating patients with evidence of residual multiple myeloma after stem cell transplantation. Lenalidomide may help shrink or slow the growth of multiple myeloma. Ixazomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving lenalidomide and ixazomib together may work better than giving lenalidomide alone in treating patients with evidence of residual multiple myeloma after a stem cell transplantation.


Sponsor


 

ClinicalTrials.gov Identifier: NCT03941860

Official Title: Optimizing Prolonged Treatment in Myeloma Using MRD Assessment (OPTIMUM)

First Posted : May 8, 2019


 
 

Drug: Ixazomib Citrate

Drug: Lenalidomide

Other: Placebo Administration

Other: Quality-of-Life Assessment

Other: Questionnaire Administration

 

Locations

United States, Illinois

United States, Iowa

United States, Kansas

United States, Massachusetts

United States, Michigan

United States, Minnesota

United States, Missouri

United States, North Dakota

United States, Ohio

United States, Oklahoma

United States, Pennsylvania

United States, South Carolina

United States, South Dakota

United States, Wisconsin

 

Other ECOG Trials


NCT04566328: Phase 3 - EAA181 / EQUATE - Testing the Use of Combination Therapy in NDMM


NCT03937635: Phase 3 - EAA173 / DETER-SMM - Lenalidomide, Dex +/- Daratumumab in High-Risk Smoldering Myeloma


NCT03941860: Phase 3 - EAA171 / OPTIMUM - Addition of Ixazomib to Lenalidomide in Patients With Residual Myeloma


NCT02465060: Phase 2 - EAY131 / NCI-MATCH - Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

 

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