- Recruiting
NCT02884102: MMRF Molecular Profiling Protocol - Multiple Myeloma Research Foundation
Updated: Apr 28, 2022
NCT02884102: MMRF Molecular Profiling Protocol
Multiple Myeloma Research Foundation
Sponsor: Multiple Myeloma Research Foundation
Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.
Genetic: genetic sequencing
Multiple Locations
ClinicalTrials.gov Identifier: NCT02884102
Official Title: Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies
First Posted : August 30, 2016
https://clinicaltrials.gov/ct2/show/NCT02884102
NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)
NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)
The Multiple Myeloma Research Consortium® (MMRC®)
What is the MMRC®?
https://themmrf.org/finding-a-cure/our-work/mmrc/
What is the MyDRUG study?
https://themmrf.org/finding-a-cure/our-work/my-drug/
NCT01454297: MMRF CoMMpass Study in Newly Diagnosed Multiple Myeloma - (CoMMpass)
NCT03657251: MMRF CureCloud Research Initiative
https://www.themyelomaclinicaltrials.com/single-post/nct03657251-mmrf-curecloud-research-initiative
- Multiple locations
- Arizona: Mayo Clinic Arizona
- California: City of Hope Duarte
- California: University of California San Francisco
- Georgia: Emory University Atlanta
- Illinois: University of Chicago
- Massachusetts: Dana-Farber Cancer Institute/Harvard Cancer Center Boston
- Massachusetts: Massachusetts General Hospital Boston
- Michigan: Barbara Ann Karmanos Cancer Institute Detroit
- Minnesota: Mayo Clinic Rochester Minnesota
- Missouri: Washington University School of Medicine Saint Louis
- New York: Tisch Cancer Institute Mount Sinai Hospital New York
- New Jersey: Hackensack University Medical Center
- North Carolina: Levine Cancer Institute Charlotte
- Texas: Baylor University Medical Center Dallas