NCT02884102: MMRF Molecular Profiling Protocol - Multiple Myeloma Research Foundation

• MMRF

NCT02884102: MMRF Molecular Profiling Protocol

Multiple Myeloma Research Foundation

Sponsor: Multiple Myeloma Research Foundation

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.

Genetic: genetic sequencing

Multiple Locations

ClinicalTrials.gov Identifier: NCT02884102

Official Title: Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies

First Posted : August 30, 2016

https://clinicaltrials.gov/ct2/show/NCT02884102

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NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)

NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)

The Multiple Myeloma Research Consortium® (MMRC®)

What is the MMRC®?

https://themmrf.org/finding-a-cure/our-work/mmrc/

What is the MyDRUG study?

https://themmrf.org/finding-a-cure/our-work/my-drug/

NCT01454297: MMRF CoMMpass Study in Newly Diagnosed Multiple Myeloma - (CoMMpass)

https://www.themyelomaclinicaltrials.com/single-post/2011/10/19/nct01454297-a-prospective-longitudinal-observational-study-in-newly-diagnosed-multiple-my

NCT03657251: MMRF CureCloud Research Initiative

https://www.themyelomaclinicaltrials.com/single-post/nct03657251-mmrf-curecloud-research-initiative

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- Multiple locations

- Arizona: Mayo Clinic Arizona

- California: City of Hope Duarte

- California: University of California San Francisco

- Georgia: Emory University Atlanta

- Illinois: University of Chicago

- Massachusetts: Dana-Farber Cancer Institute/Harvard Cancer Center Boston

- Massachusetts: Massachusetts General Hospital Boston

- Michigan: Barbara Ann Karmanos Cancer Institute Detroit

- Minnesota: Mayo Clinic Rochester Minnesota

- Missouri: Washington University School of Medicine Saint Louis

- New York: Tisch Cancer Institute Mount Sinai Hospital New York

- New Jersey: Hackensack University Medical Center

- North Carolina: Levine Cancer Institute Charlotte

- Texas: Baylor University Medical Center Dallas