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NCT04555551:Phase 1 - MCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for Multiple Myeloma

Updated: Sep 29, 2022


MCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of Multiple Myeloma


This study will test the safety of the study treatment, MCARH109, at different doses, to see which dose is safest in people, and to look for any good and bad effects of this treatment. The study treatment could stop the growth of the cancer, but it could also cause side effects.

Sponsor Identifier: NCT04555551

Official Title: Phase I Trial of G Protein-coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted MCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of Multiple Myeloma

First Posted : September 18, 2020

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GPRC5D-Targeted CAR T Cells for Myeloma

N Engl J Med; 2022 Sep 29

Conclusions: The results of this study of a GPRC5D-targeted CAR T-cell therapy (MCARH109) confirm that GPRC5D is an active immunotherapeutic target in multiple myeloma. (Funded by Juno Therapeutics/Bristol Myers Squibb; number, NCT04555551.).


827 Phase I First-in-Class Trial of MCARH109, a G Protein Coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted CAR T Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma

Program: Oral and Poster Abstracts

Type: Oral

Session: 704. Cellular Immunotherapies: Expanding Targets and Cellular Sources for Immunotherapies

Hematology Disease Topics & Pathways:

Clinical Trials, Biological, Clinical Research, Plasma Cell Disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Clinically Relevant, Diseases, Therapies, Lymphoid Malignancies

Monday, December 13, 2021: 5:30 PM


Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma

Blood Cancer Discov;2020 Sep


GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Sci Transl Med;2019 Mar 27



- MCARH109


- New York: Memorial Sloan-Kettering Cancer Center New York



United States, New York



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