- Active, not recruiting
NCT02312258: Phase 3: TOURMALINE-MM4 - Oral Ixazomib Maintenance Therapy in NDMM-TIE
Updated: Oct 4, 2022
TOURMALINE-MM4 Trial
NCT02312258: Phase 3: A Study of Oral Ixazomib Maintenance Therapy in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Not Treated With Stem Cell Transplantation (SCT)
NCT02312258: Phase 3: A Study of Oral Ixazomib Maintenance Therapy in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Not Treated With Stem Cell Transplantation (SCT)
The purpose of this study is to determine the effect of ixazomib maintenance therapy on progression free survival (PFS) compared with placebo, in participants with NDMM who have had a major response (complete response [CR], very good partial response [VGPR], or partial response [PR]) to initial therapy and who have not undergone SCT.
Sponsor
ClinicalTrials.gov Identifier: NCT02312258
Official Title: A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation
First Posted: December 9, 2014
Click here for details on ClinicalTrials.gov
Drug: Placebo
Drug: Ixazomib
MRD dynamics during maintenance for improved prognostication of 1280 myeloma patients in TOURMALINE-MM3 and -MM4 trials
Blood;2022 Sep 21
Intenational Myeloma Foundation: Measurable Residual Disease Evaluation During Ixazomib Maintenance in NDMM: TOURMALINE-MM3 and -MM4
Jun 16, 2021
Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial
J Clin Oncol; 2020
Locations
United States, California
United States, Georgia
United States, Illinois
United States, Iowa
United States, Kentucky
United States, Maine
United States, Maryland
United States, Massachusetts
United States, Michigan
United States, New York
United States, North Carolina
United States, Pennsylvania
United States, Texas
United States, Washington
United States, West Virginia
Argentina
Australia, Victoria
Austria
Belgium
Brazil
Canada, Ontario
Canada, Quebec
Asia
Europe
Chile
China, Jiangsu
China, Shanghai
China, Zhejiang
China
Colombia
Croatia
Czechia
Denmark
France
Germany
Greece
Hungary
Israel
Italy
Japan
Korea, Republic of
Mexico
Poland
Portugal
Russian Federation
Serbia
Singapore
South Africa
Spain
Sweden
Switzerland
Taiwan
Thailand
Turkey
United Kingdom
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