NCT03290950: Phase 2 - A Study of Daratumumab in Patients With NDMM wKRd-D - Manhattan Trial
- Active, not recruiting
- Dec 31, 2017
- 3 min read
Updated: Feb 21, 2024
MANHATTAN TRIAL
NCT03290950: Phase 2 - A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma
Dara-KRd
A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma
This is a study to test the safety and effectiveness of the study drug, daratumumab in combination with carfilzomib, lenalidomide and dexamethasone. The purpose of this study is to test whether giving daratumumab along with the other drugs (carfilzomib, lenalidomide and dexamethasone) is safe for patients.
Carfilzomib (Kyprolis)
Lenalidomide (Revlimid)
Dexamethasone (Decadron)
Daratumumab (Darzalex)
Sponsor
Collaborator
ClinicalTrials.gov Identifier: NCT03290950
Official Title: Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly-Diagnosed Multiple Myeloma: A Clinical and Correlative Phase II Study
First Posted : September 25, 2017
653.Myeloma: Therapy, excluding Transplantation| November 13, 2019
Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy Provides Unprecedented MRD Negativity Rates in Newly Diagnosed Multiple Myeloma: A Clinical and Correlative Phase 2 Study
Monday, December 7, 2020, 7:00 AM-3:30 PM
3204 Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy in Newly Diagnosed Multiple Myeloma: Final Results from a Clinical and Correlative Phase 2 Study
Program: Oral and Poster Abstracts
Session: 653. Myeloma/Amyloidosis: Therapy, excluding Transplantation: Poster III
Hematology Disease Topics & Pathways:
multiple myeloma, Adult, Diseases, Therapies, Combinations, Elderly, Young Adult, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Clinically relevant, Quality Improvement
JAMA Oncol; 2021 Jun
Safety and Effectiveness of Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Daratumumab Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma: The MANHATTAN Nonrandomized Clinical Trial
To assess the safety and effectiveness of carfilzomib-lenalidomide-dexamethasone-daratumumab combination therapy for patients with newly diagnosed multiple myeloma, in the absence of high-dose melphalan chemotherapy and autologous hemopoietic cell transplant.
J Clin Oncol; 2022 Jun 30
Modern Myeloma Therapy + Sustained Minimal Residual Disease-Negative = (Functional) Cure!
Locations
Memorial Sloan-Kettering Cancer Center New York
United States, New Jersey
United States, New York
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