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NCT03290950: Phase 2 - A Study of Daratumumab in Patients With NDMM wKRd-D - Manhattan Trial

Updated: Sep 25

MANHATTAN TRIAL

NCT03290950: Phase 2 - A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma

Dara-KRd

Manhattan Trial

A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma


This is a study to test the safety and effectiveness of the study drug, daratumumab in combination with carfilzomib, lenalidomide and dexamethasone. The purpose of this study is to test whether giving daratumumab along with the other drugs (carfilzomib, lenalidomide and dexamethasone) is safe for patients.


Carfilzomib (Kyprolis)

Lenalidomide (Revlimid)

Dexamethasone (Decadron)

Daratumumab (Darzalex)


Sponsor

Memorial Sloan Kettering Cancer Center


Collaborator

Janssen Pharmaceuticals

 

ClinicalTrials.gov Identifier: NCT03290950

Official Title: Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly-Diagnosed Multiple Myeloma: A Clinical and Correlative Phase II Study

First Posted : September 25, 2017

Click here for details on ClinicalTrials.gov

 

Daratumumab : National Cancer Institute

Daratumumab : MedlinePlus Drug Information


Daratumumab and Hyaluronidase-fihj Injection: National Cancer Institute

Daratumumab and Hyaluronidase-fihj Injection: MedlinePlus Drug Information


Carfilzomib : National Cancer Institute

Carfilzomib : MedlinePlus Drug Information


Dexamethasone : National Cancer Institute

Dexamethasone : MedlinePlus Drug Information


Lenalidomide: National Cancer Institute

Lenalidomide: MedlinePlus Drug Information

 

653.Myeloma: Therapy, excluding Transplantation| November 13, 2019

Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy Provides Unprecedented MRD Negativity Rates in Newly Diagnosed Multiple Myeloma: A Clinical and Correlative Phase 2 Study

Click here for details

 

Monday, December 7, 2020, 7:00 AM-3:30 PM

3204 Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy in Newly Diagnosed Multiple Myeloma: Final Results from a Clinical and Correlative Phase 2 Study

Program: Oral and Poster Abstracts

Session: 653. Myeloma/Amyloidosis: Therapy, excluding Transplantation: Poster III

Hematology Disease Topics & Pathways:

multiple myeloma, Adult, Diseases, Therapies, Combinations, Elderly, Young Adult, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Clinically relevant, Quality Improvement

Click here for details

 

JAMA Oncol; 2021 Jun

Safety and Effectiveness of Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Daratumumab Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma: The MANHATTAN Nonrandomized Clinical Trial

To assess the safety and effectiveness of carfilzomib-lenalidomide-dexamethasone-daratumumab combination therapy for patients with newly diagnosed multiple myeloma, in the absence of high-dose melphalan chemotherapy and autologous hemopoietic cell transplant.

Click here for details

 

J Clin Oncol; 2022 Jun 30

Modern Myeloma Therapy + Sustained Minimal Residual Disease-Negative = (Functional) Cure!

Click here for details

 

Locations

Memorial Sloan-Kettering Cancer Center New York

United States, New Jersey

United States, New York

 

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