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NCT04096066: Phase 3: EMN 20 - A Trial That Compare Two Treatments TIE - NDMM - KRd Vs Rd

Updated: Sep 25

NCT04096066: Phase 3: A Trial That Compare Two Treatments in Newly Diagnosed Myeloma Patients Not Eligible for Transplant (KRd vs Rd)

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krd

NCT04096066: Phase 3: A Trial That Compare Two Treatments TIE - NDMM - KRd Vs Rd


A Trial That Compare Two Treatments in Newly Diagnosed Myeloma Patients Not Eligible for Transplant (KRdvsRd)


The combination of lenalidomide plus low-dose dexamethasone (Rd) is considered the new standard for elderly newly diagnosed multiple myeloma (NDMM) patients. The combination carfilzomib plus lenalidomide-dexamethasone (KRd) in relapsed-refractory MM patients improved the progression-free survival (PFS) of approximately 1 year compared to standard Rd treatment. In a small phase 2 trial (23 pts) the KRd combination in elderly NDMM pts showed a complete response (CR) rate of 79% and a PFS at 3 years of 80%. Cardiovascular adverse events are the most limiting toxicities, especially in elderly patients.


Sponsor

Fondazione EMN Italy Onlus


Home - European Myeloma Network (myeloma-europe.org)

 

ClinicalTrials.gov Identifier: NCT04096066

Official Title: Carfilzomib - Lenalidmide - Dexamethasone (KRd) Versus Lenalidomide - Dexamethasone (Rd) in Newly Diagnosed Myeloma Patients Not Eligible for Autologous Stem Cell Transplantation: a Randomized Phas III Trial

First Posted : September 19, 2019

Click here for details on ClinicalTrials.gov


EMN20 - European Myeloma Network (myeloma-europe.org)

 

Carfilzomib : National Cancer Institute

Carfilzomib : MedlinePlus Drug Information


Lenalidomide: National Cancer Institute

Lenalidomide: MedlinePlus Drug Information


Dexamethasone : National Cancer Institute

Dexamethasone : MedlinePlus Drug Information

 

Drug: Carfilzomib

Drug: Lenalidomide

Drug: Dexamethasone

 

Locations

Europe

Italy

 

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