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NCT01402284: Phase 2 - Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients

Updated: Sep 25, 2022

NCT01402284: Phase 2 - Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients

KRd

NCT01402284

Carfilzomib is an experimental anti-cancer drug that has not yet been approved for treating multiple myeloma. Lenalidomide is a drug that may stop tumor growth and help the immune system kill cancer cells. Dexamethasone is a drug that helps stop inflammation. It is sometimes used to treat (alone or with other drugs) certain types of cancer, especially multiple myeloma. This combination of drugs has not been tested in people with multiple myeloma. Researchers want to see whether it is safe and effective for this group.

Objectives To test the effectiveness of combined carfilzomib, lenalidomide, and dexamethasone in treating multiple myeloma.


Sponsor

National Cancer Institute (NCI)


Collaborators

Celgene

Onyx Therapeutics, Inc.

 

ClinicalTrials.gov Identifier: NCT01402284

Official Title: Carfilzomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Multiple Myeloma: Clinical and Correlative Phase II Study

First Posted : July 26, 2011

Click here for details on ClinicalTrials.gov

 

Carfilzomib : National Cancer Institute

Carfilzomib : MedlinePlus Drug Information


Lenalidomide: National Cancer Institute

Lenalidomide: MedlinePlus Drug Information


Dexamethasone : National Cancer Institute

Dexamethasone : MedlinePlus Drug Information

 

Drug: Carfilzomib

Drug: Lenalidomide

Drug: Dexamethasone

 

Treatment With Carfilzomib-Lenalidomide-Dexamethasone With Lenalidomide Extension in Patients With Smoldering or Newly Diagnosed Multiple Myeloma.

JAMA Oncol. 2015 Sep

https://pubmed.ncbi.nlm.nih.gov/26181891/

 

Sci Rep; 2019

Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide

https://pubmed.ncbi.nlm.nih.gov/31619706/

 

Elife;2015

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

https://pubmed.ncbi.nlm.nih.gov/26327694/

 

Location

United States, Maryland

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, United States, 20892

 

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