• Active, not recruiting

NCT02541383: Phase 3 - Bortezomib, thalidomide, dex +/-Daratumumab before & after ASCT (CASSIOPEIA)

Updated: Sep 25

The CASSIOPEIA trial

IFM / HOVON

IFM 2015-01

HOVON HO131 MM

Newly Diagnosed Multiple Myeloma

CASSIOPEIA - myeloma trial

A Study to Evaluate Daratumumab in Transplant Eligible Participants With Previously Untreated Multiple Myeloma


The purpose of this study is to evaluate if the addition of daratumumab to Bortezomib, Thalidomide and Dexamethasone will increase the stringent complete response rate after consolidation therapy and increase the progression free survival after daratumumab maintenance therapy in transplant eligible participants with previously untreated Multiple Myeloma.


The Intergroupe Francophone du Myélome and

Dutch-Belgian Cooperative Trial Group for Hematology Oncology.

 

Sponsor

Intergroupe Francophone du Myelome

IFM


Collaborators

HOVON - Dutch Haemato-Oncology Association

Janssen Research & Development, LLC

 

ClinicalTrials.gov Identifier: NCT02541383

Official Title: Study of Daratumumab in Combination With Bortezomib (VELCADE), Thalidomide, and Dexamethasone (VTD) in the First Line Treatment of Transplant Eligible Subjects With Newly Diagnosed Multiple Myeloma

Click here to see details on ClinicalTrials.gov

IFM 2015-01

HO131 ( Other Identifier: HOVON )

2014-004781-15 ( EudraCT Number )

 

Daratumumab : National Cancer Institute

Daratumumab : MedlinePlus Drug Information


Bortezomib : National Cancer Institute

Bortezomib : MedlinePlus Drug Information

Dexamethasone : National Cancer Institute

Dexamethasone : MedlinePlus Drug Information

Thalidomide : National Cancer Institute

Thalidomide : MedlinePlus Drug Information

 

Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study

PMID: 31171419; Lancet; Jul 2019

Click here to see details.

 

Bortezomib, thalidomide, and dexamethasone with or without daratumumab for transplantation-eligible patients with newly diagnosed multiple myeloma (CASSIOPEIA): health-related quality of life outcomes of a randomised, open-label, phase 3 trial PMID: 33242444; Lancet Haematol; Dec 2020

Click here to see details.

 

DARATUMUMAB MAINTENANCE VS OBSERVATION IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA TREATED WITH BORTEZOMIB, THALIDOMIDE, AND DEXAMETHASONE ± DARATUMUMAB AND ASCT: CASSIOPEIA PART 2 RESULTS

EHA 2021 Congress - The European Hematology Association; EHA 2021 Virtual, June 12, 2021

Click here to see details on EHA website.

 

Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial

Lancet Oncol; 2021 Oct

Click here to see details.

 

82 Daratumumab (DARA) with Bortezomib, Thalidomide, and Dexamethasone (VTd) in Transplant-Eligible Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM): Analysis of Minimal Residual Disease (MRD) Negativity in Cassiopeia Part 1 and Part 2

Program: Oral and Poster Abstracts

Type: Oral

Session: 653. Myeloma and Plasma Cell Dyscrasias: Clinical-Prospective Therapeutic Trials: Phase 2 and 3 Trials in Myeloma

Hematology Disease Topics & Pathways:

Clinical Trials, Biological, Adults, Clinical Research, Plasma Cell Disorders, Diseases, Therapies, Lymphoid Malignancies, Monoclonal Antibody Therapy, Study Population

Saturday, December 11, 2021: 10:45 AM


Learn more

 

Locations

Europe

Belgium

France

Netherlands

 

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